Roche Postdoctoral Fellowship – Lysosomal signaling and dysfunction in neurodegeneration
F. Hoffmann-La Roche Ltd
Basel Headquarter,Basel-City,Switzerland,
vor 1 Tg.

The Roche Postdoctoral Fellowship (RPF) program is aimed at supporting outstanding young scientists focusing on cooperative R&D projects between Roche and international academic institutions.

As Roche Postdoctoral Fellow, you will receive scientific mentoring from both Roche and its academic partners, and gain valuable research experience from both, academic and industrial, perspectives.

Recently, it was demonstrated that the majority of Parkinson's disease patients have at least one putative damaging variant in a lysosomal storage disorder gene.

These human genetic studies reinforce the importance of lysosomal mechanisms in Parkinson's disease pathogenesis and subsequent neurodegeneration.

Neuron, which are life long-lived, post-mitotic cells, depend on an efficient proteostasis system to maintain cellular health over decades and thus slight perturbations in lysosomal homeostasis can have devastating consequences.

However, a better understanding of common lysosomal dysfunction in PD (regional vulnerability) is essential for new therapeutic approaches and the development of efficacious drugs that target lysosome dysfunction in PD.

To that end, the goal of the project is identify common mechanisms of lysosomal dysfunction triggered by the pathological oxidation of dopamine accumulation in human PD neurons.

The postdoc position is aimed at addressing key fundamental questions of lysosomal research in neurodegeneration by identifying common mechanisms of lysosomal dysfunction.

When you join our international team in an outstanding and competitive scientific environment you will hold several of these primary responsibilities :

  • Use state of the art proteomics and protocols to purify lysosomes from human neurons as well as human mid-brain dopamine from patients with genetically defined PD (GBA, SYN) derived neurons
  • Develop human stem cell neuronal models of Dopamine induced lysosomal dysfunction
  • Restore lysosomal function by targeting specific pathways with tool ASOs
  • Contribute to the understanding of molecular pathophysiology utilizing state-of-the-art molecular, cellular, proteomic, genomic and bioinformatic technologies available within Roche Pharma Research & Early Development (pRED)
  • This 2-year post-doc position will be located in Basel, Switzerland, with the possibility to extend up to four years. You can expect that a successful fellowship will result in high quality publications in peer reviewed journals.

    Your Profile :

    We are looking for a highly motivated and energetic person who recently obtained her / his PhD and has a strong interest in molecular / cellular neuroscience, lysosomal biology and neurodegeneration research.

    If you bring as well the following you are the ideal candidate for this position :

  • A strong track record based on 1st author publications
  • Hands-on experience in cellular / molecular neural biology
  • Hands-on experience in biochemistry and lysosomal biology
  • Fluency in English written and spoken
  • For questionspleasecall the Recruiting Team Switzerland : +41616822550

    Roche is an equal opportunity employer.

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    Roche is an equal opportunity employer.

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