Description du poste :
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Applications are invited to fill an ERC-funded post-doctoral position about "Sequence-function relationship in proteins" at EPFL, in the new group of Prof. Anne-Florence Bitbol.
Proteins play crucial roles in our cells. The amino-acid sequence of a protein encodes its function, including its structure and its possible interactions.
In evolution, random mutations affect the sequence, while natural selection acts at the level of function. Shedding light on the sequence-function mapping of proteins is central to a systems-level understanding of cells, and has far-reaching applications in synthetic biology and drug targeting.
The current explosion of available sequence data enables data- driven approaches to discover the principles of protein operation.
In alignments of homologous protein sequences, correlations exist between certain amino-acid sites. We aim to establish a full decomposition of these correlations, dissecting signatures from functional optimization, and from evolutionary history.
We also aim to make new predictions for protein-protein interactions from sequence data, and to understand whether real proteins are mechanically optimized
Main duties and responsibilities include :
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