(Associate/Senior) Director& Computer Aided Drug Design
Ridgeline Discovery GmbH
Basel, Basel City, Switzerland
vor 4 Tg.

Ridgeline Discovery is looking for an (Associate / Senior) Director, Computer Aided Drug Design .

Ridgeline Discovery is a Versant Ventures Discovery Engine located in Basel, Switzerland. Founded in 2017 to create and operate Versant-financed innovative biotech companies it has an international team of more than 30 highly experienced drug discovery professionals.

Since its inception, Ridgeline Discovery has built several companies from idea to IPO or advanced financing, including Black Diamond Tx (NASDAQ : BDTX), Bright Peak Tx, Monte Rosa Tx (NASDAQ : GLUE), Matterhorn Biosciences and Cimeio Tx.

As a member of the Versant Ventures family, we are part of a $ 3.2 billion healthcare venture capital firm with deep investment, operating and R&D expertise and more than 75 successful acquisitions or IPOs.

Basel, located at the German and French border, is a center of arts, science and culture and a global hub for the pharmaceutical industry.

The Director, Computer Aided Drug Design is responsible for structural design and computational R&D support to Ridgeline’s portfolio companies.

The director oversees a team of CADD scientists, machine learning specialists and data scientists supporting the entire drug discovery process from hit finding to candidate selection.

This is an exciting opportunity to take a leading role in a highly dynamic environment which integrates computer-aided drug design, computational chemistry, machine learning and artificial intelligence to move our companies forward and shape Ridgeline’s overarching scientific strategy.

The candidate will report to the SVP chemistry of Ridgeline Discovery.

The successful candidate will be highly motivated and enthusiastic with a positive can do attitude, attention to details and innovation, strong organization and communication skills, and strategic mindset.


  • Leading and contributing to design and execution of the computational strategy, activities and infrastructure for Ridgeline Discovery Engine-supported biotech companies
  • Leadership of scientists and associates within Ridgeline to further develop the computational drug discovery strategy of multiple companies
  • Design and optimize novel drug candidates by integrating protein modeling, molecular docking based on X-ray or homology models, ligand-based design, library design, diversity analysis, conformational analysis, and pharmacophore modeling
  • Drive the data science strategy to establish pipelines, to explore new artificial intelligence (AI) technologies and develop new computational approaches like bioinformatics, machine learning, or cloud-based solutions
  • Research into new computational R&D tools and methods relevant to the drug discovery and development process
  • Engage with global research, industry, and standards development communities to identify and implement new technologies and best practices

  • Ph.D. in computational chemistry, chemistry, molecular modeling, structural biology, or related field with a computational emphasis and at least 5-10 years of experience directly applied to projects in the Biotech / Pharmaceutical sector
  • Demonstrated track record of leveraging digital techniques to drive drug discovery projects or impacting hit finding activities in a drug discovery environment
  • A comprehensive understanding of data mining and visualization, ligand and structure-based design, physics-based and machine learning-based methods, conformational analysis, and pharmacophore development
  • Solid background in protein structure and experience in tools for protein analysis / design
  • Expert knowledge of modern computational drug design packages and tools, with an emphasis on molecular dynamics, structure prediction and analysis, virtual screening / docking, and free energy determination
  • Understanding of the antibody discovery and optimization process is a plus
  • Programming experience is a plus
  • Highly self-motivated, intellectually curious individual
  • Eager to work in a fast-paced, multidisciplinary start-up environment
  • Strong team player
  • In addition to a permanent position within a collaborative and exciting professional environment we offer a competitive salary, benefits package and support for both your individual and professional development.

    To apply , please send us the application form together with your CV and Cover Letter .

    Melde diesen Job

    Thank you for reporting this job!

    Your feedback will help us improve the quality of our services.

    Klicke auf "Weiter", um unseren Datenschutz-und Nutzungsbestimmungen zuzustimmen . Du kriegst außerdem die besten Jobs als E-Mail-Alert. Los geht's!