Our previous work has demonstrated a physical link between the disturbed metabolic pathway in methylmalonic aciduria and the Krebs (TCA) cycle.
Your project will use genetic (e.g. CRISPR-Cas) and pharmacological manipulation of involved enzymes, along with multi-omics technologies (e.
g. proteomics, metabolomics) and biochemical studies to investigate the interaction and inter-regulation of these pathways, in vitro and in cell models.
The goal is to identify potential entry points for nutritional complementation-based strategies, which can be translated further into animal models and the clinic.
The highly motivated candidate will
The successful candidate will ideally
What we offer
We offer a competitive employment package, as well as a supportive and highly collaborative working environment that fosters academic career development.
Zurich is a major European research hub that also offers an exceptionally high quality of life.