Postdoc position in iPSC-based modeling of human neurodevelopmental disorders
Eidgenossische Technische Hochschule Zürich, ETHZ
Zürich
vor 14 Std.
source : MyScience

Job description

We will characterize 2D and 3D iPSC-derived human cellular models of Rett and dup15q syndrome using high-throughput large-scale extracellular electrophysiology (high-density microelectrode arrays), patch-clamping and single-cell genomic methods and attempt phenotype rescues using pharmacological and gene-therapeutic interventions.

The Postdoc will collaborate and lead activities in a highly interdisciplinary project that aims at gaining mechanistic insights into neurodevelopmental disorders using a comprehensive multi-modal description of human iPSC-derived human cellular models in healthy and diseased states.

The main activities and responsibilities will include :

  • generation and maintenance of in vitro human cellular models
  • electrophysiological and optical functional characterization measurements as well as analysis of the acquired data
  • treatment interventions using pharmacological and genetic approaches
  • guidance and supervision of practical work of other team members (PhD candidates).
  • Your profile

    For this highly interdisciplinary project, you must have a PhD degree and significant research expertise in either neuroscience, stem cell biology or molecular / cell biology.

    Moreover, desirable skills include expertise in the generation of human iPSC-derived neuronal cultures, and expertise in extracellular recordings and / or whole-cell patch clamp recordings in vitro.

    Large-scale data acquisition and analysis as well as programming experience are a plus.

    Being successful in interdisciplinary work in the fields of microtechnology / medicine / biology requires excellent communication skills and a highly proactive work attitude.

    You must be able to fluently communicate in English (oral and written) and be willing to work and take over leadership in a highly interactive international environment with master and PhD candidates.

    The activities will also include project management and, potentially, the acquisition of new national and international projects.

    The position is planned for 2 years.

    We offer

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