Senior Scientist Gene Editing
Ridgeline Discovery GmbH
Basel, Basel City, Switzerland
vor 5 Tg.

Ridgeline Discovery is looking for a Senior Scientist Gene Editing .

Ridgeline Discovery is currently supporting Cimeio Therapeutics, an upcoming, innovative biotech company aiming to drastically change current treatment paradigms in targeted therapies and hematopoietic stem cell transplantation.

This Basel based position offers a tremendous opportunity to support our growing company in an experienced, vibrant, and agile biotech team.

We are seeking a highly motivated and talented individual with a strong and multi-year background in genetic engineering techniques to join our team.

The candidate will be a highly creative Senior Scientist having worked in the rapidly evolving fields of CRISPR-mediated gene editing, base editing and / or homologous directed repair.

The successful candidate will work closely with a world-class team of scientists in a highly dynamic and collaborative environment.

RESPONSIBILITIES

  • Design strategies to efficiently and safely engineer targeted gene edits into primary human immune cells
  • Establish various genome engineering platforms including HDR-based gene editing and base editing
  • Evaluate different delivery modes (e.g. AAV-based HDR templates vs. ssODN or dsODN; mRNA vs RNP etc.)
  • Evaluate and establish assays to quantify off-target editing for research and advise for the use as cell production release assays
  • Present ideas and results to the scientific and management teams
  • Stay on top of new developments in the field
  • Close interactions with the cell manufacturing team
  • QUALIFICATIONS

  • PhD Degree in Biochemistry, Biotechnology, Biomedicine, Biology, Chemistry or a related discipline
  • 4+ years’ experience in various techniques of genomic DNA editing
  • Strong understanding of one or more of the following : CRISPR / Cas9 mediated genome editing including homology directed repair and base editing
  • Experience applying genome editing in primary cells, particularly human immune cells is a plus
  • Knowledge of alternative genome engineering platforms incl. ZFN, TALENs etc.
  • Flexibility to accommodate to rapidly changing priorities and deadlines
  • Fast learner and willing to learn new skills and technologies
  • Excellent oral and written communication skills, and ability to work in a team
  • To apply , please send us this application form together with your CV and Cover Letter .

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