ADME Scientist
Basel, Basel-Stadt
vor 3 Tg.


For our client, a pharmaceutical company in Basel we are looking for an

ADME Scientist

  • Start date : Mid-April / early May
  • Contract : 1 year with possibility of extension
  • Remote / Home Office : Onsite 100% lab work
  • Background :

    Working principally on small molecule projects, we are looking for a motivated candidate to fill the gaps in the ADME field for drug development.

    The contractor will work on advancing in vitro assay techniques to estimate fractions metabolized by enzymes to support clinical PK prediction and drug-drug interaction (DDI) risk assessment for small molecules portfolios.

    The team is currently reviewing / reassessing their process and assays. They are looking into reestablishing methods and structure.

    To do so, they are looking for a scientist with expert knowledge of bioanalytics and in vitro assays.

    Tasks & Responsibilities :

  • Conduct the laboratory work in enzymology / DDI and allied experimental areas of small molecule drug metabolism as e.g.
  • incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.

  • Analyzing incubation samples via LC-MS / MS and radio-HPLC, including the method development and / or validation.
  • Plan, monitor, communicate and report enzymology / DDI studies both in a drug discovery and in drug development setting reporting to the respective laboratory staff and supervisors.
  • Perform rigorous verification and develop best practices to improve the regular enzymology / DDI assays where current approaches are inadequate.
  • Some time may be spent on supporting to develop new enzyme phenotyping methodologies and approaches.
  • Must haves :

  • PhD or Post Doc in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD) (Master are considered but higher education is preferred) ( )
  • Min 3 / 5 years of experience in similar position ( )
  • Experience in bioanalysis & in vitro assays ( )
  • Experience in industry ( )
  • Excellent knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics assessment and the respective experimental designs
  • You have a strong interest in translational approaches leveraging in vitro data and clinical data.
  • Nice to haves :

  • Competence in method development / validation for radio-HPLC (e.g. Thermo) and LC-MS / MS (e.g. Sciex). This includes troubleshooting and data analysis (e.
  • g. Analyst). Please note here experience with Sciex is really highly valued. ( )

  • Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies)
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