Data Scientist
Idorsia Pharmaceuticals Ltd
Basel, BL, CH
vor 3 Tg.

About Idorsia Pharmaceuticals Ltd

Idorsia Ltd is reaching out for more - We have more ideas, we see more opportunities and we want to help more patients.

In order to achieve this, we will develop Idorsia into one of Europe’s leading biopharmaceutical companies, with a strong scientific core.

Headquartered in Switzerland - a European biotech hub - Idorsia is specialized in the discovery and development of small molecules, to transform the horizon of therapeutic options.

Idorsia has a broad portfolio of innovative drugs in the pipeline, an experienced team, a fully-functional research center, and a strong balance sheet the ideal constellation to bringing R&D efforts to business success.

Idorsia was listed on the SIX Swiss Exchange (ticker symbol : IDIA) in June 2017 and has over 800 highly qualified specialists dedicated to realizing our ambitious targets.

We are looking for a motivated and experienced (omics) data scientist that is passionate about the digitization of pharmaceutical R&D and healthcare.

  • You have developed an extensive skill set to analyze single cell and spatial genomics datasets. You are a strong team player with outstanding communication skills.
  • You are a result-oriented professional with interests in accelerating drug discovery and development processes through agile data analysis.
  • You have an open mind and are a problem-solver with a great interest in challenging biological and pharmacological questions.
  • You are at ease with working simultaneously on several projects with different objectives.
  • By keeping up-to-date with the latest computational capabilities and data sources you can act as key player in drug discovery and early development teams to provide them with directions and decision points for progressing molecules to clinical concept testing.
  • Bridging with other computational functions and the Global Information Services (GIS) is key to the success of team in which the data scientists will be deployed.

    Job Responsibilities

    The data scientist is responsible for analyzing complex data sets obtained through in-house experiments and / or retrieved from external sources.

    We have a particular interest in single cell expression and spatial genomics analyses. You will be part of the Translational Biomarker Group whose members scientifically and experimentally engage in discovery and early clinical development teams to solve project-related questions.

    By working closely together with other functions in scientific computing and (biomedical) statistics within a matrix organization, you will present and discuss analysis results with projects teams.

    The data scientist will be further responsible for :

  • Driving the exploration and validation of novel drug targets and / or biomarkers
  • Continuous improvement of analytical procedures; evaluation, validation and implementation of new tools and methodologies
  • Developing and constantly innovating the Translational Biomarker strategy for Idorsia
  • Documenting, reporting, and communicating results to the teams
  • Publishing, presenting, and discussing scientific results at international meetings; Be a representative of the Biomarker strategy in Idorsia towards an international expert audience.
  • Developing standardized NGS analysis pipelines and workflows : Data storage, data management, data retrieval with queries, data visualization and biological data interpretation based on the biological questions
  • Effectively communicate project context and results with team members in the Translational Biomarkers, Biology and Pharmacology groups
  • Candidate’s Requirements

  • A PhD in bioinformatics or any other relevant life sciences discipline with demonstrated experience in complex data analysis of omics data sets
  • Minimally 5 years postdoctoral experience of applying advanced types of data analysis, proven by a strong publication record or 2 years Industry experience
  • Strong experience with the processing and biological interpretation of sequencing data from different single cell technologies, including methods for full-length (e.
  • g. SmartSeq2) and UMI-based (e.g. 10X Genomics’ Chromium, Drop-seq, InDrops) profiling. Experience in working with CyTOF data would be an asset

  • Expertise in creating and working with atlas -level cross-study single cell datasets. In particular, experience in integration of in-house data with commercially curated studies towards the comparison and identification of disease and compound signatures at the cell and molecular level
  • Experience working with multi-modal single cell and / or spatial omics data, and the ability to effectively correlate these with other high-dimensional readouts towards a deep phenotypic characterization of disease-associated cell populations, in particular in the context of infiltrating immune cell populations
  • Demonstrated ability to test and / or develop new computational tools to draw relevant biological insight from bulk and single cell transcriptomic data with respect to target validation, compound mode of action and translatable biomarkers
  • Expert knowledge in omics information resources and more advanced pathway / biological network analysis
  • Experience in one or more therapeutic areas of interest to Idorsia (CNS, Immunology, Oncology, and CV / fibrosis) would be an advantage
  • Demonstrated experience of working in multicultural, multidisciplinary and matrix environments
  • Result oriented, problem solver with a good understanding of biology in multiple therapeutic areas preferably with experience in a medical setting
  • Background in computational analysis, experienced in statistical analysis with good scripting and programming skills (e.
  • g. shell, R / bioconductor, Python, Java)

  • Experience in dashboard creation (such as R shiny app) would be an advantage
  • Experience with cloud computing, pipeline development and productionizing data analysis workflows desiredDynamic team player with excellent communication and networking skills, flexible mindset and scientifically curious
  • Exemplifying core values of trust and teamwork in project teams to maximize their effectiveness.
  • Full professional proficiency in English
  • What Idorsia offers

  • Exciting opportunities for development and professional growth within our dynamic organization
  • A collaborative and solution-oriented environment where you can make a difference
  • An innovative and open culture in a truly multicultural environment
  • A competitive salary and generous social benefits
  • Work Location : Allschwil

    Country : Switzerland

    Business Area : Drug Discovery Biology Translational Biomarkers

    Job ID : 2536

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