PhD-Student Immunometabolism and Microbiota in Obesity 100% | befristet
Insel Gruppe
Bern, CH
vor 21 Std.
source : 100000jobs.ch

As a leading university hospital with a rich tradition, the Inselspital is part of the Insel Group and is a centre ofmedical expertise and high technology with an international reputation as well as being a first-class training andresearch centre.

PhD-Student Immunometabolism and Microbiota in ObesityMedical area Abdomen & MetabolismDepartment for Diabetology, Endocrinology, Nutrition und MetabolyResearch 100% in Bern Entry on 01.

11.2021 or after agreementLimited position for 3 - 4 years Obesity and diabetes, both rapidly increasing in prevalence worldwide, have atremendous medical and socio-economic impact.

Both are multifactorial in their etiology, influenced by genetic andenvironmental factors. Obesity and Diabetes also share the characteristic of a chronic low-grade inflammatory statethat indicates that altered metabolism may alter the immune system.

The gut microbiota, and microbial metabolites inparticular, have been described to play an important role in disease development.

However, the underlying mechanismsare still ill defined.In our lab, we will apply innovative gnotobiotic, metagenomic and metabolomic approaches to advance our mechanisticunderstanding of the complex pathophysiologic interplay between gut microbiota, metabolism and inflammation drivingobesity and diabetes, with the ultimate goal to inspire novel and innovative strategies for prevention and therapy ofthese important diseases.

The challengeHow is microbiota metabolism changed during diet-induced obesity? The aim of this project is to characterize themetabolome of the gut microbiota during diet-induced obesity in a gnotobiotic mouse model.

Manipulation of themicrobial composition and bacterial engineering will be used to influence development and treatment of diet-inducedobesity.

How does the changing metabolome in diet-induced obesity influence immune functionality? The aim of this project is toelucidate how the obesity-driving metabolome impacts on immune cell metabolism, function at the molecular level, andstudy how these changes might contribute to chronic inflammation in obesity.

Manipulating immune cell metabolismaccordingly will allow to assess causality and elucidate its therapeutic potential.Your profileWe are looking for highly talented and motivated people with a strong interest and background in immunology,microbiology and / or metabolism who are willing to independently work on, and develop, a research project.

Experiencewith animal experiments and bioinformatics is an advantage. Applicants should be fluent in English.The packageThe lab wishes to create best possible conditions for young talents to network, be creative and develop their ownideas.

You will be able to interact and train with highly skilled experts in the fields of immunology, cell biology,metabolism and microbiology.

Our lab strives to have members with a diversity of backgrounds and identities. Westrongly believe that diversity, interdisciplinarity fosters creativity and excellence, and it is our priority to makeall group members feel welcome, respected and supported.

ContactFor further information please contactProf. Dr. Maria Luisa Balmer,Research Group Leader,Phone +41 31 63 2 40 70Your applicationPlease only apply online.

Code number 12314The Insel GroupThe Insel Group forms Switzerland's largest full-service medical care system - from primary care through tostate-of-the-art medicine - that is available to everyone in the country.

This ensures that every patient is treatedat the most appropriate place for them and has access to the latest technologies, methods and medical options at alltimes.

Your place of work Inselspital, Universitätsspital BernFreiburgstrasse, CH-3010 BernSchweiz Our strengths your benefits Top training organisation As a university hospital and the leading traininginstitution in Canton Bern, the Inselspital offers training in 36 out of 44 possible medical disciplines.

In their roleas training organisations, the university clinics and institutes of the Insel Group are rated with an "A" the highestclassification.

In addition, the Insel Group offers practical training and CPD (continuous professional development) for all healthprofessions up to specialist nursing care.

It offers a broad range of vocational traineeships for its trainees, whocurrently number 300. Fostering personal development and career paths We are keen to foster personal development amongour staff.

Career opportunities and relevant models are transparent; CPD is provided with generous support. Women andcareers Gender equality and the advancement of women are a big priority for us.

Our career paths and models aredesigned so that part-time work and family responsibilities are no obstacles to taking on responsibility at ourcompany.

Individual working time arrangements Flexible working hours, part-time work and job-sharing. We are keen toaccommodate the needs of our staff where the role and operating requirements of the hospital allow.

This also appliesto our executive-grade roles. Children's day care and kindergarten We offer 115 childcare places for around 180children up to pre-school age at various locations.

At the Inselspital site, there is also a group for babies from thefourth month and a private kindergarten. Generous holiday arrangements As a family-friendly employer, the Insel Groupprovides generous schemes for unpaid leave, short remunerated breaks and parental leave in the event of the birth of achild or an adoption.

Fathers also receive 15 working days paid paternity leave. Extra days of leave are offered by wayof a loyalty bonus from as early as the fifth year of service! Attractive workplace Bern and its region assume acentral role in Switzerland.

With its enviable infrastructure, rapid links to the country's major conurbations,proximity to urban and rural districts and variety of wonderful recreational areas, Bern and its environs offer anunusually high quality of life.

Exceptional benefits The social package we offer is far above the industry average. Ourbenefits are exceptional, particularly in the case of maternity leave, continued payment of salary in the event ofsickness and accident, and full payment of daily sickness allowance or group health insurance premiums.

Meaningfuldiversity and equal opportunities We provide medical excellence with a human touch and respect for one another.

As abig business we create a unique family atmosphere through meaningful diversity within the Insel Group. Inductionprogrammes For us it is very important new employees undergo a well prepared and thorough induction.

We give youdetailed information about your new employer at a monthly welcome event and also provide tailored induction programmesin the clinics, institutes and administrative departments.

Award-winning catering Every site operated by the InselGroup has one or more staff restaurants. Our staff appreciate the quality, variety and creativity of our catering,which has repeatedly won prestigious gastronomy prizes.

Innovation and research Innovations in medicine and researchare only possible if we continue to develop. Rapid developments in the medical field bring about extraordinaryprocesses of change as well as prospects for individual development for you.

Our valuesHumanityRespect and a high regard for the individual are central to everything we do.CompetenceWe have confidence in our abilitiesand share our knowledge for the benefit of all our patients.

QualityOur actions comply with the highest standards of quality and safety.InnovationWe seek new approaches as well as promote research and innovation.

CooperationWe treat one another with respect and appreciation, foster professional cooperation and promote interdisciplinarity.

IntegrityWe are committed to our values and are guided by sincerity, transparency and dependability.Facts and figuresFacts and figures- 6 sites in the canton of Bern- Over 10,000 employees from around 80 countries- Over 300 trainees in 16 vocational fields- 15,185 placement / training weeks (at tertiary level, medical and other professions)- Around 500,000 patients, including over 60,750 inpatients- 1st class : the Inselspital is the leading Swiss university hospital in terms of patient satisfaction.

University hospital (highly specialist care, all disciplines) City hospital Tiefenau (comprehensive primary care andsecondary care) Rural hospitals (primary care close to home) Apply

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