Postdoctoral position in the field of liver diseases and cancer at the Faculty of Medicine, University of Geneva, Switzerland
Faculty of Medicine, University of Geneva
Geneva, Switzerland
vor 3 Tg.

Employer

Foti laboratory, Dept. of Cell Physiology & Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland

Position and assignments

We are inviting applications for a postdoctoral position in the Dept. of Cell Physiology & Metabolism at the Faculty of Medicine in Geneva, University of Geneva, Switzerland.

Patients with severe stages of non-alcoholic fatty liver disease (NAFLD), i.e. steatohepatitis, fibrosis and cirrhosis, present a high risk of developing hepatocellular carcinoma (HCC), an aggressive cancer with limited, and often inefficient, therapeutic options.

Unfortunately, the worldwide incidence of HCC with NAFLD is continuously raising in particular due to the current obesity pandemic.

Multiple deregulated molecular mechanisms are known to contribute to these hepatic diseases. In this regard, we recently identified S100A11 as an oncogene overexpressed with NASH / fibrosis and fostering hepatocytes carcinogenesis.

The goal of the proposed project is to further investigate the role of S100A11, and other isoforms in this family, in the steatosis transition to NASH / fibrosis, and in the initiation and progression of HCC.

The function and prophylactic / therapeutic impact of members of the S100A family in NASH / fibrosis and HCC will be examined in various mouse models of these diseases through innovative approaches, as well as in functional human liver organoids (HLO), which can reproduce various features of these heterogeneous human pathologies.

These studies should provide important and novel insights into the fundamental role of these poorly characterized S100A proteins in the pathophysiology of liver NASH / fibrosis and cancer.

They should also evaluate the potential interest of S100A proteins as new and robust biomarkers and / or therapeutic targets.

The postdoctoral position is for 3-5 years (salary : 81’347-85’945 CHF / year)

Geographic mobility :

Profile

We are looking for a strongly motivated and enthusiastic candidate with experience in molecular and cellular biology, cell culture, liver pathophysiology, and mouse experimentation.

Candidates for the postdoctoral position should be fluent in English (speaking and writing) and hold a Ph.D or M.D. Experience in hepatology and cancer biology is well appreciated.

Goals

To be established after an interview

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