100% position for 4 years, earliest starting date : 1 January 2022
The Swiss Nanoscience Institute (SNI) at the University of Basel invites highly motivated scientists to apply for the SNI PhD program in Nanoscience.
For most tumors surgical dissection is still the most applied and effective treatment; however, it remains a challenge to secure the complete removal of the tumor.
Explicitly the dissection of tumors with tendency to infiltrate the surrounding tissue within the peritoneal cavity. Intraoperative visualization of tumors can support the surgeon to see the edge of the tumor 1 .
Hence tumor cells are targeted with biocompatible gold nanoparticles functionalized with antibody binding members of the EGFR family (anti-EGFR GNPs), on their overexpressed epidermal growth factor-receptors (EGFR) and confirmed with surface enhanced Raman spectroscopy (SERS) 2 .
Thereby nanoparticle distribution, SERS signal strength and target selectivity is crucial and depends either on surface chemistry but also on GNP size and shape.
Within this PhD project, we aim to determine the effect of GNP sizes (60-5nm) and shapes (e.g. spheres, rods, triangles) to optimize target selectivity and distribution.
Moreover, we will address the SERS intensity limit caused by GNP-diameter, by using assemblies of small GNPs (
Candidates are required to have a MS degree in natural sciences, preferably with a solid background in the topics described above, as well as good English language skills.
We seek a scientifically ambitious individual who enjoys working in an interdisciplinary and collaborative environment on a highly competitive subject.
We offer you
The successful candidate will join an attractive interdisciplinary programme together with the 30 currently supported scientists.
The SNI covers a wide variety of topics, including cutting edge quantum physics and chemistry, material science, nanotechnology, biochemistry, cell biology, or medical research.
Application / Contact